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Zafeiris Anna

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Zafeiris Anna
Studying epistatic interactions in protein evolution with measurements and machine learning techniques

Aug 31 - csütörtök

11:50 – 12:10

Elméleti biofizika

E43

Studying epistatic interactions in protein evolution with measurements and machine learning techniques

Anna Zafeiris¹, Imre Derényi^1,2 and Gergely Szöllősi^1,2

¹ “Lendület” Evolutionary Genomics Research Group of the Hungarian Academy of Science

² Department of Biological Physics, Eötvös University

Epistasis is the phenomenon that a mutation in a gene or amino acid sequence modifies the effect of another mutation in the same sequence. Since this phenomenon limits the viable evolutionary paths between sequences, it can serve as an important tool in studying evolution and reconstructing evolutionary trajectories. However, due to its combinatorial complexity – originating from the vast amount of possible mutation orders – full studies on its structure and extension is scarce. In the present talk I shell overview some recent advances on protein language model based machine learning techniques along with experimental results.