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Bioorthogonally activated photoresponsive systems -
Aug 29 - kedd
08:50 – 09:10
Molekuláris biofizika
E02
Bioorthogonally activated photoresponsive systems
Péter Kele1
1 Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences
Photoresponsive materials offer excellent spatiotemporal control over biological processes and the emerging phototherapeutic methods are expected to have significant effects on targeted cancer therapies. Recent examples show that combination of photoactivatable approaches with bioorthogonal chemistry enhances the precision of targeted phototherapies and profound implications are anticipated particularly in the treatment of non-operable tumors. The extra level of on-target selectivity and improved spatial/temporal control considerably intensified related bioorthogonally assisted phototherapy research [1].
The Chemical Biology Research Group made several efforts toward the more efficient control of photoresponsivity using bioorthogonal reactions as triggers. The knowledge we gained upon the development of simple probes [2] through more complex red-emitting fluorogenic scaffolds [3] was applied to gain control of the photoresponsivity of photolabile protecting groups (photocages) that paves the way for the highly precise activation of drugs in response to a specific ligation reaction and light [4]. The concept of conditional photoactivation can be extended to more complex systems in the future. The presentation gives a brief overview of the milestones of this track.
References
[1] Kozma et al. Angew. Chem. Int. Ed. 2022, 62, e202303198.
[2] Kormos et al. Chem. Eur. J. 2018, 24, 8841; Kozma et al. Chem. Commun. 2017, 53, 6696.
[3] Albitz et al. Angew. Chem. Int. Ed. 2022, 61, e202111855; Kormos et al. Chem. Commun. 2020, 56, 5425; Kormos et al. Chemosensors 2022, 10, 37.
[4] Bojtár et al. J. Am. Chem. Soc. 2020, 142, 15164; Egyed et al. J. Am. Chem. Soc. 2023, 145, 4026.