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Halmóczki Sarolta

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Halmóczki Sarolta
A comprehensive review of various metal-containing nanoparticles in terms of their antibacterial effect and cytotoxic properties

Aug 29 - kedd

15:30 – 17:00

I. Poszterszekció

P10

A comprehensive review of various metal-containing nanoparticles in terms of their antibacterial effect and cytotoxic properties

Sarolta Halmóczki, Angéla Jedlovszky-Hajdú

Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University

One of the main reasons, why the healing of chronic wounds is highly challenging is the emergence of multidrug-resistant bacteria. These wounds usually cannot be treated effectively with conventional antibiotics, therefore, alternative methods and agents are investigated to replace them. [1] [2] In this regard, metal nanoparticles (MeNPs) could be promising substances, because they possess significant antimicrobial activity, with the advantage that bacteria are unlikely to develop resistance against them. [3] On the other hand, application of MeNPs may be challenging, since their toxic effect against microorganisms is not selective, and they additionally carry cytotoxic effect. [2] Numerous research articles have been published, which examine the potential of using different MeNPs for wound healing applications. However, it would be invaluable to have a review article that compares the antimicrobial and cytotoxic properties of the most promising MeNPs.

More than 50 scientific articles have been studied, regarding the wound healing potential of silver, gold, copper-, iron- and zinc containing nanoparticles. In the comparison, the main focus was on the antimicrobial activity and cytotoxic effect. Numerous types of Gram-positive and Gram-negative bacteria was treated with metal nanoparticles. In most of the cases, MeNPs were not on their own, rather in a hydrogel, or along with other agents, such as traditional antibiotics. Cytotoxicity was tested on various malignant and normal cell lines. Several cytotoxicity-reducing methods were exhibited, but in general, the effect of the MeNPs is dose-, shape- and size-dependent, but exposition time and the exact cell line used are also not negligible factors.

Acknowledgment

This research was supported by NKFIH FK 137749

References

[1] C. Liao, Y. Li, S.C. Tjong, Bactericidal and cytotoxic properties of silver nanoparticles, Int. J. Mol. Sci. 20 (2019). https://doi.org/10.3390/ijms20020449.

[2] N. Naderi, D. Karponis, A. Mosahebi, A.M. Seifalian, Nanoparticles in wound healing; from hope to promise, from promise to routine, Front. Biosci. - Landmark. 23 (2018) 1038–1059. https://doi.org/10.2741/4632.

[3] L. Wang, C. Hu, L. Shao, The antimicrobial activity of nanoparticles: Present situation and prospects for the future, Int. J. Nanomedicine. 12 (2017) 1227–1249. https://doi.org/10.2147/IJN.S121956.