Összes szerző
Domokos Judit
az alábbi absztraktok szerzői között szerepel:
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Pálos Veronika
Salt loaded fibrous meshes from polysuccinimide for medical applications -
Aug 29 - kedd
15:30 – 17:00
I. Poszterszekció
P20
Salt loaded fibrous meshes from polysuccinimide for medical applications
Veronika Pálos1, Judit Domokos2, Dóra Szabó2, Ákos Zsembery3, Rita Pázmány1, Krisztina S.-Nagy1, Angéla Jedlovszky-Hajdú1
1 Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University
2 Institute of Medical Microbiology, Semmelweis University
3 Institute of Oralbiology, Semmelweis University
Silver is increasingly being pushed out of medicine, and other ions with antibacterial effect are coming to the forefront. This is because since silver ions have huge environmental burden.
The aim of my research is to create a bicomponent polymer network by electrospinning, which contains zinc and strontium salts in addition to the polymer, which according to the literature, have antibacterial properties. If such a new type of biocompatible wound dressing could be created, not only would be a mechanical barrier to infection but also have antibacterial activity against microorganisms.
The first step was to synthesize the polymer, then mix it with the selected inorganic salts in dimethylformamide, and then optimize the electrostatic fiber formation parameters. The inorganic salts used in the experiments were Zn(O2CCH3)2 and Sr(NO3)2. Next, the chemical and mechanical properties of the complete polymer networks were investigated by FTIR spectroscopy, SEM images, and their mechanical behavior through specific load capacity. In the next step, I investigated the antibacterial effect of polymer networks containing inorganic salts on four different bacterial species.
Based on FTIR spectroscopy, the salts formed a physical bond with polysuccinimide, but there was no chemical bonding between them. SEM of a polymer mesh containing inorganic salts showed a big difference between the fiber diameters in the presence of the salts. However, no difference was found in their specific load capacity. In antibacterial experiments, a more significant clearance zone appeared for the polymer containing Zn(O2CCH3)2, and a lesser inhibition zone for those containing Sr(NO3)2 salts. The next step was to find out if the polymer meshes with the salts have cytotoxic activity against human tumor and fibroblast cells, because these fibrous structures are going to use as wound dressing, so they must interact with the human cells.
Acknowledgment
The work was supported by the National Research, Development, and Innovation Office FK137749 and TKP 2021-EGA-23.