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Balázs Katalin

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Balázs Katalin
Acute and long-lasting immunological changes in prostate cancer patients treated with three different radiotherapy protocols

Aug 29 - kedd

15:30 – 17:00

I. Poszterszekció

P01

Acute and long-lasting immunological changes in prostate cancer patients treated with three different radiotherapy protocols

Katalin Balázs^1,2, Zsolt Jurányi³, Zsuzsa Kocsis S³, Géza Sáfrány¹, Katalin Lumniczky¹

¹ National Public Health Center, Budapest, Hungary

² Doctoral School of Pathological Sciences, Semmelweis University, Budapest, Hungary

³ National Institute of Oncology, Budapest, Hungary

Radiotherapy can modify systemic immune responses of cancer patients. However, little is known about how long these alterations persist in patients successfully cured of cancer. We investigated how prostate cancer and radiotherapy impact the innate and adaptive immune system of cancer patients treated with various radiotherapy protocols in order to mark potential immune-related biomarkers for patient follow-up.

Blood samples were collected from 63 patients treated with three different type of radiotherapy protocols (LDR brachytherapy: n=21; HDR brachytherapy: n=22; LINAC-based teletherapy: n=20 patients) before and at 7 time points after the therapy up to 36 months. Phenotypical changes in peripheral blood mononuclear cells were analysed by multicolor flow cytometry.

Natural killer (NK) cells were among the most strongly altered in all prostate cancer patients. LDR therapy induced very moderate changes within the NK subpopulation, however teletherapy caused a strong and persistent shift toward immature NK cells. The proportion of non-senescent and senescent CD4+ and CD8+ T cells changed very similarly in HDR and teletherapy groups; the balance shifted strongly to the senescent populations during the follow-up. We further investigated the amount of PSA-containing macrophages which level increased several folds in cancer patients before therapy compared to control and found positive correlation between the plasma PSA level and the level of circulating PSA+ macrophages before therapy.

Our studies demonstrate that prostate cancer patients show long-lasting immunological changes. Furthermore different radiotherapy protocols lead to different long-term immune alterations highlighting the importance of deposition kinetics of ionizing radiation energy in modulating systemic immune responses.

This work was supported by a Hungarian research grant funded by the National Research, Development, and Innovation Office (NKFI-124879).